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Systemic Anti-Cancer Therapy Regimen Library

Home > LEU ALL precursor B-cell BCR-ABL1+ - HyperCVAD with RITUximab and daSATinib Part A and B followed by Maintenance [60 years and under] > LEU - HyperCVAD with daSATinib Maintenance
This regimen is a component of LEU ALL precursor B-cell BCR-ABL1+ - HyperCVAD with RITUximab and daSATinib Part A and B followed by Maintenance [60 years and under]

Maintenance with daSATinib (LEU ALL precursor B-cell BCR-ABL1+ - HyperCVAD with RITUximab and daSATinib Part A and B followed by Maintenance [60 years and under])

Treatment Overview

Follows HyperCVAD Cycle 4B.

Not used for transplant patients.

Cycles 1 to 8 - 84 days

Cycle length:
84

daSATinib:

  • daSATinib 50 mg ONCE daily if in complete molecular response.
  • Or dose based on individual patient response and tolerability.
  • Early molecular relapse may necessitate a dose increase.
  • Continue treatment indefinitely.

Intrathecal metHOTREXATe: For Ommaya reservoir reduce dose to 6 mg intraventricularly.

Cycle details

Cycles 1 to 8 - 84 days

Medication Dose Route Days Max Duration
daSATinib * 50 mg Once daily oral administration 1 to 84
vinCRISTine 2 mg flat dosing intravenous 1 10 minutes
metHOTREXATe 12 mg flat dosing intrathecal injection 1
prEDNISone 200 mg flat dosing Once daily oral administration 1 to 5

daSATinib:

  • daSATinib 50 mg ONCE daily if in complete molecular response.
  • Or dose based on individual patient response and tolerability.
  • Early molecular relapse may necessitate a dose increase.
  • Continue treatment indefinitely.

Intrathecal metHOTREXATe: For Ommaya reservoir reduce dose to 6 mg intraventricularly.

Full details

Cycles 1 to 8 - 84 days

Day: 1

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
vinCRISTine 2 mg flat dosing intravenous 10 minutes
Instructions:
  • Diluted in a minibag.
  • FOR INTRAVENOUS USE ONLY – fatal if given by any other routes.
  • Warning vesicant—ensure vein is patent prior to administration, administer vesicant as per institutional policy and monitor for signs of extravasation throughout administration.
metHOTREXATe 12 mg flat dosing intrathecal injection
Instructions:
  • Adhere to local institution policy for intrathecal administration.
  • For Ommaya reservoir reduce dose to 6 mg intraventricularly.
prEDNISone 200 mg flat dosing Once daily oral administration
Instructions:

Take in the morning with food.

Day: 2

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
prEDNISone 200 mg flat dosing Once daily oral administration
Instructions:

Take in the morning with food.

Day: 3

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
prEDNISone 200 mg flat dosing Once daily oral administration
Instructions:

Take in the morning with food.

Day: 4

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
prEDNISone 200 mg flat dosing Once daily oral administration
Instructions:

Take in the morning with food.

Day: 5

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
prEDNISone 200 mg flat dosing Once daily oral administration
Instructions:

Take in the morning with food.

Day: 6

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 7

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 8

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 9

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 10

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 11

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 12

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 13

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 14

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 15

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 16

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 17

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 18

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 19

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 20

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 21

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 22

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 23

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 24

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 25

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 26

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 27

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 28

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 29

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 30

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 31

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 32

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 33

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 34

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 35

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 36

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 37

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 38

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 39

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 40

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 41

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 42

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 43

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 44

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 45

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 46

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 47

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 48

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 49

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 50

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 51

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 52

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 53

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 54

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 55

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 56

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 57

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 58

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 59

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 60

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 61

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 62

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 63

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 64

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 65

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 66

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 67

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 68

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 69

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 70

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 71

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 72

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 73

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 74

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 75

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 76

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 77

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 78

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 79

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 80

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 81

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 82

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 83

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Day: 84

Medication Dose Route Max duration Details
daSATinib * 50 mg Once daily oral administration
Instructions:
  • Or dose based on individual patient response and tolerability.
  • Continue indefinitely.
  • Swallow whole, do not crush or chew with a large glass of water.
  • Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.

Supportive Care Factors

Factor Value
Antiviral prophylaxis for herpes virus: Routine antiviral prophylaxis recommended
Constipation risk: Variable
Diarrhoea risk: Variable
Emetogenicity: Minimal to low
Gastroprotection: Gastroprotection is recommended
Pneumocystis jirovecii pneumonia (PJP) prophylaxis: Routine antibiotic prophylaxis recommended

Antiviral prophylaxis for hepatitis B virus: Guidance is limited to high-risk anti-cancer medicines. Clinicians will need to assess individual patient risk for other anti-cancer medicines.


Constipation/Diarrhoea risk: vinCRISTine may cause constipation and daSATinib may cause diarrhoea. Monitor gastrointestinal symptoms. 


Gastroprotection:

  • Gastroprotective agents are only intended for short term use while patient is receiving corticosteroid treatment doses.
  • Gastroprotective agents such as proton pump inhibitors and H2 receptor antagonists are not recommended to be used with daSATinib because they may reduce exposure to daSATinib by increasing gastric pH. Consider using an antacid as an alternative.

References

Bristol-Myers Squibb (NZ) LTD. Sprycel New Zealand Datasheet 24 November 2023. https://www.medsafe.govt.nz/profs/datasheet/s/Spryceltab.pdf (Accessed 30 April 2024).

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.